Structure of PDB 2bp1 Chain A

Receptor sequence
>2bp1A (length=323) Species: 9606 (Homo sapiens) [Search protein sequence]
RVASVLGTMEMGRRMDAPASAAAVRAFLERGHTELDTAFMYSDGQSETIL
GGLGLGLGGGDCRVKIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVD
LFYLHAPDHGTPVEETLHACQRLHQEGKFVELGLSNYASWEVAEICTLCK
SNGWILPTVYQGMYNATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGK
YKYEDKDGKQPVGRFFGNSWAETYRNRFWKEHHFEAIALVEKALQAAYGA
SAPSVTSAALRWMYHHSQLQGAHGDAVILGMSSLEQLEQNLAATEEGPLE
PAVVDAFNQAWHLVAHECPNYFR
3D structure
PDB2bp1 Structure of the Aflatoxin Aldehyde Reductase in Complex with Nadph
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.n11: succinic semialdehyde reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NDP A G44 M46 R51 D73 Y78 H142 Q198 Y226 N227 P228 L229 G231 G232 T235 K237 R251 I315 G317 M318 S319 Q323 Q326 N327 G7 M9 R14 D36 Y41 H105 Q161 Y189 N190 P191 L192 G194 G195 T198 K200 R214 I278 G280 M281 S282 Q286 Q289 N290
Gene Ontology
Molecular Function
GO:0004032 aldose reductase (NADPH) activity
GO:0004033 aldo-keto reductase (NADPH) activity
GO:0005515 protein binding
GO:0009055 electron transfer activity
GO:0016491 oxidoreductase activity
GO:0019119 phenanthrene-9,10-epoxide hydrolase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006081 cellular aldehyde metabolic process
GO:0006629 lipid metabolic process
GO:0044597 daunorubicin metabolic process
GO:0044598 doxorubicin metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0070062 extracellular exosome

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Molecular Function
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Cellular Component
External links
PDB RCSB:2bp1, PDBe:2bp1, PDBj:2bp1
PDBsum2bp1
PubMed
UniProtO43488|ARK72_HUMAN Aflatoxin B1 aldehyde reductase member 2 (Gene Name=AKR7A2)

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