Structure of PDB 2bji Chain A

Receptor sequence

>2bjiA (length=274) Species: 9913 (Bos taurus)

DPWQECMDYAVTLAGQAGEVVREALKNEMNIMVKSSPADLVTATDQKVEK
MLITSIKEKYPSHSFIGEESVAAGEKSILTDNPTWIIDPIDGTTNFVHGF
PFVAVSIGFVVNKKMEFGIVYSCLEDKMYTGRKGKGAFCNGQKLQVSHQE
DITKSLLVTELGSSRTPETVRIILSNIERLLCLPIHGIRGVGTAALNMCL
VAAGAADAYYEMGIHCWDVAGAGIIVTEAGGVLLDVTGGPFDLMSRRVIA
SSNKTLAERIAKEIQIIPLQRDDE

3D structure

• PDB: 2bji High-resolution structure of myo-inositol monophosphatase, the putative target of lithium therapy.
• Chain: A
• Resolution: 1.24 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): D1090 I1092 D1093 D1220
• Catalytic site (residue number reindexed from 1): D88 I90 D91 D218
• Enzyme Commision number: 3.1.3.25: inositol-phosphate phosphatase.
  3.1.3.94: D-galactose 1-phosphate phosphatase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MG	A	E1070 D1090 I1092	E68 D88 I90
BS02	MG	A	D1090 D1093 D1220	D88 D91 D218

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0008934 inositol monophosphate 1-phosphatase activity
• GO:0016787 hydrolase activity
• GO:0030145 manganese ion binding
• GO:0031403 lithium ion binding
• GO:0046872 metal ion binding
• GO:0052832 inositol monophosphate 3-phosphatase activity
• GO:0052833 inositol monophosphate 4-phosphatase activity
• GO:0052834 inositol monophosphate phosphatase activity

Biological Process

• GO:0006020 inositol metabolic process
• GO:0006021 inositol biosynthetic process
• GO:0007165 signal transduction
• GO:0046854 phosphatidylinositol phosphate biosynthetic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:2bji, PDBe:2bji, PDBj:2bji
• PDBsum: 2bji
• PubMed: 15858264
• UniProt: P20456|IMPA1_BOVIN Inositol monophosphatase 1 (Gene Name=IMPA1)