Structure of PDB 2bj4 Chain A

Receptor sequence

>2bj4A (length=218) Species: 9606 (Homo sapiens) [Search protein sequence]

SLALSLTADQMVSALLDAEPPILYSEPFSEASMMGLLTNLADRELVHMIN
WAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLL
LDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVY
TFLSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLI
LSHIRHMSNKGMEHLYSM

3D structure

PDB

2bj4 Delineation of a Unique Protein-Protein Interaction Site on the Surface of the Estrogen Receptor

Chain

Resolution

2.0 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	L320 E323 P324 P325 I326 W393 E397 Q441 G442 E443 E444 A493	L16 E19 P20 P21 I22 W84 E88 Q132 G133 E134 E135 A183
BS02	OHT	A	L346 T347 A350 D351 E353 W383 M421 G521 L525	L37 T38 A41 D42 E44 W74 M112 G211 L215	BindingDB: IC50=0.790000nM,EC50=10.3nM,Ki=5.7nM

External links

PDB	RCSB:2bj4, PDBe:2bj4, PDBj:2bj4
PDBsum	2bj4
PubMed	15728727
UniProt	P03372\|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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