Structure of PDB 2bgg Chain A

Receptor sequence

>2bggA (length=395) Species: 2234 (Archaeoglobus fulgidus)

LTYRIGNGASVPISNTGELIKGLRNYGPYEVPSLKYNQIALIHNNQFSSL
INQLKSQISSKIDEVWHIHNINISEFIYDSPHFDSIKSQVDNAIDTGVDG
IMLVLPEYNTPLYYKLKSYLINSIPSQFMRYDILSNRNLTFYVDNLLVQF
VSKLGGKPWILNVDPEKGSDIIIGTGATRIDNVNLFCFAMVFKKDGTMLW
NEISPIVTSSEYLTYLKSTIKKVVYGFKKSNPDWDVEKLTLHVSGKRPKM
KDGETKILKETVEELKKQEMVSRDVKYAILHLNETHPFWVMEGTKVKLSS
KRYLLTLLQPYVTPIKPLSVEIVSDNWTSEEYYHNVHEILDEIYYLSKMN
WRGFRSRNLPVTVNYPKLVAGIIANVNRYGGYPINRSLQTNPWFL

3D structure

• PDB: 2bgg Structural Insights Into Mrna Recognition from a Piwi Domain-Sirna Guide Complex
• Chain: A
• Resolution: 2.2 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	Y123 K127 Q137 F138 R140 Y152 N155 L156 Q159 K163 Y331 R380 R385 L427	Y113 K117 Q127 F128 R130 Y142 N145 L146 Q149 K153 Y311 R352 R357 L395
BS02	rna	A	N25 T26 G27 R147 N148 F151 L328 Q329 P330 Y331 R383	N15 T16 G17 R137 N138 F141 L308 Q309 P310 Y311 R355
BS03	MN	A	Q159 L427	Q149 L395

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003677 DNA binding
• GO:0003723 RNA binding
• GO:0046872 metal ion binding

External links

• PDB: RCSB:2bgg, PDBe:2bgg, PDBj:2bgg
• PDBsum: 2bgg
• PubMed: 15800628
• UniProt: O28951|PIWI_ARCFU Piwi protein (Gene Name=AF_1318)