Structure of PDB 2bf6 Chain A

Receptor sequence
>2bf6A (length=448) Species: 1502 (Clostridium perfringens) [Search protein sequence]
VEGAVKTEPVDLFHPGFLNSSNYRIPALFKTKEGTLIASIDARRHGGADA
PNNDIDTAVRRSEDGGKTWDEGQIIMDYPDKSSVIDTTLIQDDETGRIFL
LVTHFPSKYGFWNAGLGSGFKNIDGKEYLCLYDSSGKEFTVRENVVYDKD
SNKTEYTTNALGDLFKNGTKIDNINSSTAPLKAKGTSYINLVYSDDDGKT
WSEPQNINFQVKKDWMKFLGIAPGRGIQIKNGEHKGRIVVPVYYTNEKGK
QSSAVIYSDDSGKNWTIGESPNDNRKLENGKIINSKTLSDDAPQLTECQV
VEMPNGQLKLFMRNLSGYLNIATSFDGGATWDETVEKDTNVLEPYCQLSV
INYSQKVDGKDAVIFSNPNARSRSNGTVRIGLINQVGTYENGEPKYEFDW
KYNKLVKPGYYAYSCLTELSNGNIGLLYEGTPSEEMSYIEMNLKYLES
3D structure
PDB2bf6 The Structure of Clostridium Perfringens Nani Sialidase and its Catalytic Intermediates.
ChainA
Resolution0.97 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) A290 D291 E539 Y655
Catalytic site (residue number reindexed from 1) A48 D49 E297 Y413
Enzyme Commision number 3.2.1.18: exo-alpha-sialidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SIA A R266 I267 D291 I327 D328 F353 Y485 Q493 R555 R615 K646 Y655 E689 S690 R24 I25 D49 I85 D86 F111 Y243 Q251 R313 R373 K404 Y413 E447 S448
BS02 CA A D296 D298 D319 Y320 D54 D56 D77 Y78
BS03 CA A D515 N516 W573 D273 N274 W331
Gene Ontology
Molecular Function
GO:0004308 exo-alpha-sialidase activity

View graph for
Molecular Function
External links
PDB RCSB:2bf6, PDBe:2bf6, PDBj:2bf6
PDBsum2bf6
PubMed18218621
UniProtQ59310

[Back to BioLiP]