Structure of PDB 2bcp Chain A

Receptor sequence
>2bcpA (length=473) Species: 1314 (Streptococcus pyogenes) [Search protein sequence]
GQQMGRTLYDDDDKDRWGSKIVVVGANHAGTACIKTMLTNYGDANEIVVF
DQNSNISFLGSGMALWIGEQIAGPEGLFYSDKEELESLGAKVYMESPVQS
IDYDAKTVTALVDGKNHVETYDKLIFATGSQPILPPIKGAEIKEGSLEFE
ATLENLQFVKLYQNSADVIAKLENKDIKRVAVVGAGYIGVELAEAFQRKG
KEVVLIDVVDTCLAGYYDRDLTDLMAKNMEEHGIQLAFGETVKEVAGNGK
VEKIITDKNEYDVDMVILAVGFRPNTTLGNGKIDLFRNGAFLVNKRQETS
IPGVYAIGDCATIYDNATRDTNYIALASNAVRTGIVAAHNACGTDLEGIG
VQGSNGISIYGLHMVSTGLTLEKAKRLGFDAAVTEYTDNQKPEFIEHGNF
PVTIKIVYDKDSRRILGAQMAAREDVSMGIHMFSLAIQEGVTIEKLALTD
IFFLPHFNKPYNYITMAALGAKD
3D structure
PDB2bcp Structural Analysis of Streptococcus pyogenes NADH Oxidase: Conformational Dynamics Involved in Formation of the C(4a)-Peroxyflavin Intermediate.
ChainA
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H11 I39 G43 S44 V314
Catalytic site (residue number reindexed from 1) H28 I56 G60 S61 V331
Enzyme Commision number 1.6.3.4: NADH oxidase (H2O-forming).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AZI A G43 S44 G60 S61
BS02 FAD A V7 G8 N10 H11 A12 D34 Q35 G43 S44 V81 A110 T111 G112 K143 Y170 I171 G291 D292 L309 A310 V24 G25 N27 H28 A29 D51 Q52 G60 S61 V98 A127 T128 G129 K160 Y187 I188 G308 D309 L326 A327
Gene Ontology
Molecular Function
GO:0008137 NADH dehydrogenase (ubiquinone) activity
GO:0016491 oxidoreductase activity
Biological Process
GO:1902600 proton transmembrane transport

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Molecular Function
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Biological Process
External links
PDB RCSB:2bcp, PDBe:2bcp, PDBj:2bcp
PDBsum2bcp
PubMed26506002
UniProtQ5XC60|NAOX_STRP6 NADH oxidase (Gene Name=M6_Spy0868)

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