Structure of PDB 2bc9 Chain A

Receptor sequence
>2bc9A (length=294) Species: 9606 (Homo sapiens) [Search protein sequence]
ASEIHMTGPMCLIENTNGRLMANPEALKILSAITQPMVVVAIVGLYRTGK
SYLMNKLAGKKKGFSLGSTVQSHTKGIWMWCVPHPKKPGHILVLLDTEGL
GDVEKGDNQNDSWIFALAVLLSSTFVYNSIGTINQQAMDQLYYVTELTHR
IRSKSDFVSFFPDFVWTLRDFSLDLEADGQPLTPDEYLTYSLKLKKGTSQ
KDETFNLPRLCIRKFFPKKKCFVFDRPVHRRKLAQLEKLQDEELDPEFVQ
QVADFCSYIFSNSKTKTLSGGIQVNGPRLESLVLTYVNAISSGD
3D structure
PDB2bc9 How guanylate-binding proteins achieve assembly-stimulated processive cleavage of GTP to GMP.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.-
3.6.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A S52 T75 S51 T74
BS02 GNP A Y47 R48 G50 K51 S52 Y53 L67 G68 S69 H74 T75 G100 R183 D184 P241 L247 L250 Y46 R47 G49 K50 S51 Y52 L66 G67 S68 H73 T74 G99 R169 D170 P227 L233 L236
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:2bc9, PDBe:2bc9, PDBj:2bc9
PDBsum2bc9
PubMed16511497
UniProtP32455|GBP1_HUMAN Guanylate-binding protein 1 (Gene Name=GBP1)

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