Structure of PDB 2bbs Chain A

Receptor sequence
>2bbsA (length=253) Species: 9606 (Homo sapiens) [Search protein sequence]
STTEVVMENVTAFWEEGFGELFEKAKGTPVLKDINFKIERGQLLAVAGST
GAGKTSLLMMIMGELEPSEGKIKHSGRISFCSQNSWIMPGTIKENIIGVS
YDEYRYRSVIKACQLEEDISKFAEKDNIVLITLSGGQRARISLARAVYKD
ADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADK
ILILHEGSSYFYGTFSELQNLRPDFSSKLMSFDQFSAERRNSILTETLHR
FSL
3D structure
PDB2bbs Structure and dynamics of NBD1 from CFTR characterized using crystallography and hydrogen/deuterium exchange mass spectrometry.
ChainA
Resolution2.05 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 5.6.1.6: channel-conductance-controlling ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A T465 Q493 T55 Q83
BS02 ATP A W401 V440 G461 G463 K464 T465 S466 Q493 W14 V30 G51 G53 K54 T55 S56 Q83
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity

View graph for
Molecular Function
External links
PDB RCSB:2bbs, PDBe:2bbs, PDBj:2bbs
PDBsum2bbs
PubMed19944699
UniProtP13569|CFTR_HUMAN Cystic fibrosis transmembrane conductance regulator (Gene Name=CFTR)

[Back to BioLiP]