Structure of PDB 2bbo Chain A

Receptor sequence
>2bboA (length=254) Species: 9606 (Homo sapiens) [Search protein sequence]
TTEVVMENVTAFWEEGLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLM
MIMGELEPSEGKIKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRS
VIKACQLEEDISKFAEKDNIVLGEGGITLSEGQQAKISLARAVYKDADLY
LLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKILIL
HEGSSYFYGTFSELQNLQPDFSSKLMSFDQFSAERRNSILTETLRRFSLE
GDAP
3D structure
PDB2bbo Structure and dynamics of NBD1 from CFTR characterized using crystallography and hydrogen/deuterium exchange mass spectrometry.
ChainA
Resolution2.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.1.6: channel-conductance-controlling ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A T465 Q493 T46 Q74
BS02 ATP A W401 G461 G463 K464 T465 S466 Q493 Y577 W13 G42 G44 K45 T46 S47 Q74 Y158
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity

View graph for
Molecular Function
External links
PDB RCSB:2bbo, PDBe:2bbo, PDBj:2bbo
PDBsum2bbo
PubMed19944699
UniProtP13569|CFTR_HUMAN Cystic fibrosis transmembrane conductance regulator (Gene Name=CFTR)

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