Structure of PDB 2bb6 Chain A

Receptor sequence

>2bb6A (length=414) Species: 9913 (Bos taurus) [Search protein sequence]

NICEITEVDSTLVERLGQRLLPWMDRLSQEQLNPSIYVGLRLSSLQAGAK
EAHYLHSLKLSYQQSLLRPASNKDDNDSEAKPSMGQLALYLLALRANCEF
IGGRKGDRLVSQLKRFLEDEKRAIGHNHQGHPRTSYYQYSLGILALCVHQ
KRVHDSVVGKLLYAVEHKPHLLQDHVSVDTMAMAGMAFSCLELSNLNPKQ
RNRINLALKRVQEKILKAQTPEGYFGNVYSTPLALQLLMGSLRPSVELGT
ACLKAKAALQASLQHKTFQNPLMISQLLPVLNQKSYVDLISPDCQAPRAL
LEPALETPPQAKVPKFIDVLLKVSGISPSYRHSVSVPAGSSLEDILKNAQ
EHGRFRFRTQASLSGPFLTSVLGRKAGEREFWQVLRDPDTPLQQGIADYR
PKDGETIELRLVGW

3D structure

PDB

2bb6 Structural basis for mammalian vitamin B12 transport by transcobalamin.

Chain

Resolution

2.0 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	B12	A	G85 Q86 Y137 Q138 H175 V176 D179 N227 Y229 S230 M273 S362 L363 S364 G365 P366 F367 L368 F381 W382 Q383 V384 L392 Q393 G395 W414	G85 Q86 Y137 Q138 H175 V176 D179 N227 Y229 S230 M273 S362 L363 S364 G365 P366 F367 L368 F381 W382 Q383 V384 L392 Q393 G395 W414

Gene Ontology

	Molecular Function
GO:0031419	cobalamin binding
GO:0046872	metal ion binding

	Biological Process
GO:0006824	cobalt ion transport
GO:0015889	cobalamin transport

	Cellular Component
GO:0005576	extracellular region
GO:0005615	extracellular space

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:2bb6, PDBe:2bb6, PDBj:2bb6
PDBsum	2bb6
PubMed	16537422
UniProt	Q9XSC9\|TCO2_BOVIN Transcobalamin-2 (Gene Name=TCN2)

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