Structure of PDB 2b9i Chain A

Receptor sequence
>2b9iA (length=338) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
MPKRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKP
LFALRTLREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDL
HRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCD
LKVCDFGLARIIDEVEFVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAE
LFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPM
YPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQTYHDP
NDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNEIFS
3D structure
PDB2b9i The role of docking interactions in mediating signaling input, output, and discrimination in the yeast MAPK network.
ChainA
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D137 K139 N142 D155 T185
Catalytic site (residue number reindexed from 1) D137 K139 N142 D155 T170
Enzyme Commision number 2.7.11.24: mitogen-activated protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A E69 D112 H113 Y119 S147 N148 C149 D150 Y312 D314 D317 E69 D112 H113 Y119 S147 N148 C149 D150 Y297 D299 D302
BS02 MG A N142 D155 N142 D155
BS03 ADP A L19 V27 A40 K42 M96 D99 S141 L144 C154 D155 L19 V27 A40 K42 M96 D99 S141 L144 C154 D155
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004707 MAP kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0042802 identical protein binding
GO:0106310 protein serine kinase activity
Biological Process
GO:0000749 response to pheromone triggering conjugation with cellular fusion
GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion
GO:0001403 invasive growth in response to glucose limitation
GO:0006468 protein phosphorylation
GO:0010526 retrotransposon silencing
GO:0016310 phosphorylation
GO:0035556 intracellular signal transduction
GO:0043409 negative regulation of MAPK cascade
GO:0046827 positive regulation of protein export from nucleus
GO:0051301 cell division
GO:0071507 pheromone response MAPK cascade
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0010494 cytoplasmic stress granule
GO:0042597 periplasmic space
GO:0043332 mating projection tip

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:2b9i, PDBe:2b9i, PDBj:2b9i
PDBsum2b9i
PubMed16364919
UniProtP16892|FUS3_YEAST Mitogen-activated protein kinase FUS3 (Gene Name=FUS3)

[Back to BioLiP]