Structure of PDB 2b8w Chain A

Receptor sequence
>2b8wA (length=288) Species: 9606 (Homo sapiens) [Search protein sequence]
HMTGPMCLIENTNGRLMANPEALKILSAITQPMVVVAIVGLYRTGKSYLM
NKLAGKKKGFSLGSTVQSHTKGIWMWCVPHPKKPGHILVLLDTEGLGDVE
KGDNQNDSWIFALAVLLSSTFVYNSIGTINQQAMDQLYYVTELTHRIRSK
SVSFFPDFVWTLRDFSLDLEADGQPLTPDEYLTYSLKLKKGTSQKDETFN
LPRLCIRKFFPKKKCFVFDRPVHRRKLAQLEKLQDEELDPEFVQQVADFC
SYIFSNSKTKTLSGGIQVNGPRLESLVLTYVNAISSGD
3D structure
PDB2b8w How guanylate-binding proteins achieve assembly-stimulated processive cleavage of GTP to GMP.
ChainA
Resolution2.22 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.-
3.6.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A S52 T75 S47 T70
BS02 ALF A Y47 R48 H74 T75 G100 Y42 R43 H69 T70 G95
BS03 5GP A R48 T49 G50 K51 S52 G68 R183 D184 P241 L250 R43 T44 G45 K46 S47 G63 R163 D164 P221 L230
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:2b8w, PDBe:2b8w, PDBj:2b8w
PDBsum2b8w
PubMed16511497
UniProtP32455|GBP1_HUMAN Guanylate-binding protein 1 (Gene Name=GBP1)

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