Structure of PDB 2b7q Chain A

Receptor sequence
>2b7qA (length=273) Species: 210 (Helicobacter pylori) [Search protein sequence]
MEIRTFLERALKEDLGHGDLFERVLEKDFKATAFVRAKQEGVFSGEKYAL
ELLEMTGIECVQTIKDKERFKPKDALMEIRGDFSMLLKVERTLLNLLQHS
SGIATLTSRFVEALNSHKVRLLDTRKTRPLLRIFEKYSVLNGGASNHRLG
LDDALMLKDTHLRHVKDLKSFLTHARKNLPFTAKIEIECESFEEAKNAMN
AGADIVMCDNLSVLETKEIAAYRDAHYPFVLLEASGNISLESINAYAKSG
VDAISVGALIHQATFIDMHMKMA
3D structure
PDB2b7q Crystal structure of quinolinic acid phosphoribosyltransferase from Helicobacter pylori
ChainA
Resolution3.31 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R91 K126 K158 E188 D209
Catalytic site (residue number reindexed from 1) R91 K126 K158 E188 D209
Enzyme Commision number 2.4.2.19: nicotinate-nucleotide diphosphorylase (carboxylating).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NCN A T124 R125 H147 R148 M156 E188 M207 D209 S235 G257 H261 T124 R125 H147 R148 M156 E188 M207 D209 S235 G257 H261
Gene Ontology
Molecular Function
GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity
GO:0016757 glycosyltransferase activity
GO:0016763 pentosyltransferase activity
Biological Process
GO:0009435 NAD biosynthetic process
GO:0019363 pyridine nucleotide biosynthetic process
GO:0034213 quinolinate catabolic process
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:2b7q, PDBe:2b7q, PDBj:2b7q
PDBsum2b7q
PubMed16419067
UniProtO25909|NADC_HELPY Probable nicotinate-nucleotide pyrophosphorylase [carboxylating] (Gene Name=nadC)

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