Structure of PDB 2b3y Chain A

Receptor sequence
>2b3yA (length=888) Species: 9606 (Homo sapiens) [Search protein sequence]
SNPFAHLAEPLDPVQPGKKFFNLNKLEDSRYGRLPFSIRVLLEAAIRNCD
EFLVKKQDIENILHWNVTQHKNIEVPFKPARVILQDFTGVPAVVDFAAMR
DAVKKLGGDPEKINPVCPADLVIDHSIQVDFNRRADSLQKNQDLEFERNR
ERFEFLKWGSQAFHNMRIIPPGSGIIHQVNLEYLARVVFDQDGYYYPDSL
VGTDSHTTMIDGLGILGWGVGGIEAEAVMLGQPISMVLPQVIGYRLMGKP
HPLVTSTDIVLTITKHLRQVGVVGKFVEFFGPGVAQLSIADRATIANMCP
EYGATAAFFPVDEVSITYLVQTGRDEEKLKYIKKYLQAVGMFRDFNDPSQ
DPDFTQVVELDLKTVVPCCSGPKRPQDKVAVSDMKKDFESCLGAKQGFKG
FQVAPEHHNDHKTFIYDNTEFTLAHGSVVIAAITSCTNTSNPSVMLGAGL
LAKKAVDAGLNVMPYIKTSLSPGSGVVTYYLQESGVMPYLSQLGFDVVGY
GCMTCIGNSGPLPEPVVEAITQGDLVAVGVLSGNRNFEGRVHPNTRANYL
ASPPLVIAYAIAGTIRIDFEKEPLGVNAKGQQVFLKDIWPTRDEIQAVER
QYVIPGMFKEVYQKIETVNESWNALATPSDKLFFWNSKSTYIKSPPFFEN
LTLDLQPPKSIVDAYVLLNLGDSVTTDHISPAGNIARNSPAARYLTNRGL
TPREFNSYGSRRGNDAVMARGTFANIRLLNRFLNKQAPQTIHLPSGEILD
VFDAAERYQQAGLPLIVLAGKEYGAGSSRDWAAKGPFLLGIKAVLAESYE
RIHRSNLVGMGVIPLEYLPGENADALGLTGQERYTIIIPENLKPQMKVQV
KLDTGKTFQAVMRFDTDVELTYFLNGGILNYMIRKMAK
3D structure
PDB2b3y Crystal structure of human iron regulatory protein 1 as cytosolic aconitase
ChainA
Resolution1.85 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D125 H126 D205 R536 S778 R780
Catalytic site (residue number reindexed from 1) D124 H125 D204 R535 S777 R779
Enzyme Commision number 4.2.1.3: aconitate hydratase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SF4 A H126 I176 H178 H207 S436 C437 C503 C506 I507 H125 I175 H177 H206 S435 C436 C502 C505 I506
Gene Ontology
Molecular Function
GO:0000900 mRNA regulatory element binding translation repressor activity
GO:0003723 RNA binding
GO:0003994 aconitate hydratase activity
GO:0005515 protein binding
GO:0016829 lyase activity
GO:0030350 iron-responsive element binding
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
GO:0051538 3 iron, 4 sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0006099 tricarboxylic acid cycle
GO:0006101 citrate metabolic process
GO:0006417 regulation of translation
GO:0006879 intracellular iron ion homeostasis
GO:0009791 post-embryonic development
GO:0010040 response to iron(II) ion
GO:0010468 regulation of gene expression
GO:0017148 negative regulation of translation
GO:0050892 intestinal absorption
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0070062 extracellular exosome

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Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:2b3y, PDBe:2b3y, PDBj:2b3y
PDBsum2b3y
PubMed16407072
UniProtP21399|ACOHC_HUMAN Cytoplasmic aconitate hydratase (Gene Name=ACO1)

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