Structure of PDB 2b3v Chain A

Receptor sequence
>2b3vA (length=167) Species: 9606 (Homo sapiens) [Search protein sequence]
FVIRPATAADCSDILRLIKELARYEYMEEQVILTEKDLLEDGFGEHPFYH
CLVAEVPKEHWTPEGHSIVGFAMYYFTYDPWIGKLLYLEDFFVMSDYRGF
GIGSEILKNLSQVAMRCRCSSMHFLVAEWNEPSINFYKRRGASDLSSEEG
WRLFKIDKEYLLKMATE
3D structure
PDB2b3v Structures of wild-type and mutant human spermidine/spermine N1-acetyltransferase, a potential therapeutic drug target.
ChainA
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.57: diamine N-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ACO A Y27 F94 F95 V96 R101 G102 F103 G104 G106 S107 L128 S136 F139 Y140 R142 R143 Y24 F91 F92 V93 R98 G99 F100 G101 G103 S104 L125 S133 F136 Y137 R139 R140
Gene Ontology
Molecular Function
GO:0004145 diamine N-acetyltransferase activity
GO:0005515 protein binding
GO:0008080 N-acetyltransferase activity
GO:0016746 acyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
GO:0019809 spermidine binding
GO:0042802 identical protein binding
Biological Process
GO:0001525 angiogenesis
GO:0006596 polyamine biosynthetic process
GO:0009447 putrescine catabolic process
GO:0032918 spermidine acetylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2b3v, PDBe:2b3v, PDBj:2b3v
PDBsum2b3v
PubMed16455797
UniProtP21673|SAT1_HUMAN Diamine acetyltransferase 1 (Gene Name=SAT1)

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