Structure of PDB 2b1p Chain A

Receptor sequence
>2b1pA (length=331) Species: 9606 (Homo sapiens) [Search protein sequence]
NQFYSVEVGDSTFTVLKRYQNLKPIGSGGIVCAAYDAVLDRNVAIKKLSR
PFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVME
LMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVV
KSDCTLKILDFGLTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKIL
FPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKL
FPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVW
YDPAEVEAPPPDEREHTIEEWKELIYKEVMN
3D structure
PDB2b1p Design and synthesis of 6-anilinoindazoles as selective inhibitors of c-Jun N-terminal kinase-3
ChainA
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D189 K191 N194 D207 T226
Catalytic site (residue number reindexed from 1) D142 K144 N147 D160 T164
Enzyme Commision number 2.7.11.24: mitogen-activated protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AIZ A A91 K93 L144 M146 M149 D150 A151 N152 Q155 A44 K46 L97 M99 M102 D103 A104 N105 Q108 MOAD: ic50=3nM
PDBbind-CN: -logKd/Ki=8.52,IC50=3nM
BindingDB: IC50=3nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004707 MAP kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2b1p, PDBe:2b1p, PDBj:2b1p
PDBsum2b1p
PubMed16140012
UniProtP53779|MK10_HUMAN Mitogen-activated protein kinase 10 (Gene Name=MAPK10)

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