Structure of PDB 2b0f Chain A

Receptor sequence
>2b0fA (length=182) Species: 12131 (rhinovirus B14) [Search protein sequence]
GPNTEFALSLLRKNIMTITTSKGEFTGLGIHDRVCVIPTHAQPGDDVLVN
GQKIRVKDKYKLVDPENINLELTVLTLDRNEKFRDIRGFISEDLEGVDAT
LVVHSNNFTNTILEVGPVTMAGLINLSSTPTNRMIRYDYATKTGQCGGVL
CATGKIFGIHVGGNGRQGFSAQLKKQYFVEKQ
3D structure
PDB2b0f NMR solution structures of the apo and peptide-inhibited human rhinovirus 3C protease (Serotype 14): structural and dynamic comparison
ChainA
ResolutionN/A
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H40 E71 G144 C146
Catalytic site (residue number reindexed from 1) H40 E71 G144 C146
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.28: picornain 3C.
3.4.22.29: picornain 2A.
3.6.1.15: nucleoside-triphosphate phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K22 H40 E71 I124 N125 L126 S127 S128 K142 T143 G144 C146 H160 V161 G162 G163 N164 F169 K22 H40 E71 I124 N125 L126 S127 S128 K142 T143 G144 C146 H160 V161 G162 G163 N164 F169
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2b0f, PDBe:2b0f, PDBj:2b0f
PDBsum2b0f
PubMed17944485
UniProtP03303|POLG_HRV14 Genome polyprotein

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