Structure of PDB 2axi Chain A

Receptor sequence
>2axiA (length=92) Species: 9606 (Homo sapiens) [Search protein sequence]
EQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQ
HIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQE
3D structure
PDB2axi Structure-Activity Studies in a Family of beta-Hairpin Protein Epitope Mimetic Inhibitors of the p53-HDM2 Protein-Protein Interaction.
ChainA
Resolution1.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K51 L54 F55 G58 I61 Y67 Q72 F86 F91 V93 H96 K29 L32 F33 G36 I39 Y45 Q50 F64 F69 V71 H74
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:2axi, PDBe:2axi, PDBj:2axi
PDBsum2axi
PubMed16511824
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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