Structure of PDB 2ath Chain A

Receptor sequence
>2athA (length=271) Species: 9606 (Homo sapiens) [Search protein sequence]
ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLM
MGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGF
VNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSL
RKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPI
EDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVI
KKTETDMSLHPLLQEIYKDLY
3D structure
PDB2ath Novel indole-based peroxisome proliferator-activated receptor agonists: design, SAR, structural biology, and biological activities
ChainA
Resolution2.28 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3EA A F282 G284 C285 R288 S289 H323 L330 I341 M364 H449 Y473 F76 G78 C79 R82 S83 H117 L124 I135 M158 H243 Y267 MOAD: ic50=0.152uM
PDBbind-CN: -logKd/Ki=6.82,IC50=0.152uM
BindingDB: IC50=152nM,EC50=230nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2ath, PDBe:2ath, PDBj:2ath
PDBsum2ath
PubMed16366601
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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