Structure of PDB 2arq Chain A

Receptor sequence

>2arqA (length=360) Species: 9606 (Homo sapiens)

DLCVANTLFALNLFKHLAKASPTQNLFLSPWSISSTMAMVYMGSRGSTED
QMASVLQFNEDKIHSSFRSLSSAINASTGNYLLESVNKLFGEKSASFREE
YIRLCQKYYSSEPQAVDFLECAEEARKKINSWVKTQTKGKIPNLLPEGSV
DGDTRMVLVNAVYFKGKWKTPFEKKLLFPFRVNSAQRTPVQMMYLREKLN
IGYIEDLKAQILELPYAGDVSMFLLLPDADVSTGLELLESEITYDKLNKW
TSKDKMAEDEVEVYIPQFKLEEHYELRSILRSMGMEDAFNKGRANFSGMS
ERNDLFLSEVFHQAMVDVNEEGTGRTGHGGPQFVADHPFLFLIMHKITNC
ILFFGRFSSP

3D structure

• PDB: 2arq Plasminogen activator inhibitor-2 is highly tolerant to P8 residue substitution--implications for serpin mechanistic model and prediction of nsSNP activities
• Chain: A
• Resolution: 1.85 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	T38 K180 L184 D193 T194 R195 M196 V197 L198 V199 N200 A201 V202 Y203 F204 K205 G206 W208 Y258 K335 A338 F340 N347 D348 L349 F350 L351 S352 E353 V354 F355 H356 Q357 A358 M359 V360 D361 V362 N363 F408	T36 K140 L144 D153 T154 R155 M156 V157 L158 V159 N160 A161 V162 Y163 F164 K165 G166 W168 Y216 K291 A294 F296 N303 D304 L305 F306 L307 S308 E309 V310 F311 H312 Q313 A314 M315 V316 D317 V318 N319 F353

Gene Ontology

Molecular Function

• GO:0004867 serine-type endopeptidase inhibitor activity

Biological Process

• GO:0010466 negative regulation of peptidase activity
• GO:0042730 fibrinolysis
• GO:0043066 negative regulation of apoptotic process

Cellular Component

• GO:0001533 cornified envelope
• GO:0005576 extracellular region
• GO:0005615 extracellular space
• GO:0005737 cytoplasm
• GO:0005886 plasma membrane

External links

• PDB: RCSB:2arq, PDBe:2arq, PDBj:2arq
• PDBsum: 2arq
• PubMed: 16214170
• UniProt: P05120|PAI2_HUMAN Plasminogen activator inhibitor 2 (Gene Name=SERPINB2)