Structure of PDB 2aoa Chain A

Receptor sequence
>2aoaA (length=93) Species: 9606 (Homo sapiens) [Search protein sequence]
HPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQH
FKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRD
3D structure
PDB2aoa Crystal Structures of a High-affinity Macrocyclic Peptide Mimetic in Complex with the Grb2 SH2 Domain.
ChainA
Resolution1.99 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 S1S A R67 R86 S88 E89 S90 S96 H107 F108 K109 L111 L120 R10 R29 S31 E32 S33 S39 H50 F51 K52 L54 L63
BS02 S1S A D113 K117 R142 D56 K60 R85
External links
PDB RCSB:2aoa, PDBe:2aoa, PDBj:2aoa
PDBsum2aoa
PubMed16165154
UniProtP62993|GRB2_HUMAN Growth factor receptor-bound protein 2 (Gene Name=GRB2)

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