Structure of PDB 2ao6 Chain A

Receptor sequence
>2ao6A (length=242) Species: 9606 (Homo sapiens) [Search protein sequence]
PIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAK
ALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVF
NEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDG
LKNQKFFDELRMNYIKELDRIIATSCSRRFYQLTKLLDSVQPIARELHQF
TFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHT
3D structure
PDB2ao6 Structural basis for androgen receptor interdomain and coactivator interactions suggests a transition in nuclear receptor activation function dominance
ChainA
Resolution1.89 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V716 K720 R726 V730 M734 Q738 M894 E897 V46 K50 R56 V60 M64 Q68 M218 E221
BS02 R18 A L704 N705 Q711 M745 M749 F764 T877 L34 N35 Q41 M75 M79 F94 T201 PDBbind-CN: -logKd/Ki=9.28,Kd=0.52nM
BindingDB: Kd=0.99nM,IC50=0.302000nM,EC50=0.013000nM,Ki=0.400000nM
External links
PDB RCSB:2ao6, PDBe:2ao6, PDBj:2ao6
PDBsum2ao6
PubMed15525515
UniProtP10275|ANDR_HUMAN Androgen receptor (Gene Name=AR)

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