Structure of PDB 2anl Chain A

Receptor sequence
>2anlA (length=327) Species: 5858 (Plasmodium malariae) [Search protein sequence]
SENDVIELDDVANLMFYGEGEVGDNHQKFMLIFDTGSANLWVPSKKCNSI
GCSTKHLYDSSKSKSYEKDGTKVEITYGSGTVRGFFSKDLVTLGYLSLPY
KFIEVTDTDDLEPLYTAAEFDGILGLGWKDLSIGSIDPIVVELKNQNKID
QALFTFYLPVHDKHSGYLTIGGIEEKFYEGELTYEKLNHDLFWQVDLDVN
FGKTSMEKANVIVDSGTSTITAPTSFINKFFKDLNVIKVPFLPFYITTCN
NKDMPTLEFKSANNTYTLEPEYYMEPLLDIDDTLCMLYILPVDIDKNTFI
LGDPFMRKYFTVFDYDKESIGFAVAKN
3D structure
PDB2anl Structure of the aspartic protease plasmepsin 4 from the malarial parasite Plasmodium malariae bound to an allophenylnorstatine-based inhibitor.
ChainA
Resolution3.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D34 S37 N39 W41 Y77 D214 T217
Catalytic site (residue number reindexed from 1) D34 S37 N39 W41 Y77 D214 T217
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 JE2 A D34 G36 Y77 G78 S79 L131 F192 D214 T217 V292 D34 G36 Y77 G78 S79 L131 F192 D214 T217 V292 PDBbind-CN: -logKd/Ki=6.96,Ki=110nM
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2anl, PDBe:2anl, PDBj:2anl
PDBsum2anl
PubMed16510971
UniProtO60990

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