Structure of PDB 2an6 Chain A

Receptor sequence
>2an6A (length=191) Species: 10090 (Mus musculus) [Search protein sequence]
NSVLFPCKYASSGCEITLPHTEKAEHEELCEFRPYSCPCPGASCKWQGSL
DAVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGFHFML
VLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPR
SIHEGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC
3D structure
PDB2an6 Elucidation of the substrate binding site of Siah ubiquitin ligase
ChainA
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A D162 V164 F165 L166 T168 L172 V176 D177 W178 M180 N276 D71 V73 F74 L75 T77 L81 V85 D86 W87 M89 N185
BS02 peptide A H111 T112 H20 T21
BS03 ZN A C98 C105 H117 C121 C7 C14 H26 C30
BS04 ZN A C128 C135 H147 H152 C37 C44 H56 H61
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007275 multicellular organism development
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:2an6, PDBe:2an6, PDBj:2an6
PDBsum2an6
PubMed16615911
UniProtP61092|SIA1A_MOUSE E3 ubiquitin-protein ligase SIAH1A (Gene Name=Siah1a)

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