Structure of PDB 2ama Chain A

Receptor sequence
>2amaA (length=243) Species: 9606 (Homo sapiens) [Search protein sequence]
PIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAK
ALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVF
NEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDG
LKNQKFFDELRMNYIKELDRIIATSCSRRFYQLTKLLDSVQPIARELHQF
TFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHTQ
3D structure
PDB2ama Comparison of crystal structures of human androgen receptor ligand-binding domain complexed with various agonists reveals molecular determinants responsible for binding affinity.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DHT A L704 N705 M745 M749 F764 T877 M895 L34 N35 M75 M79 F94 T201 M219 PDBbind-CN: -logKd/Ki=8.00,IC50=10nM
BindingDB: IC50=>10000nM,EC50=6nM,Ki=0.2nM
External links
PDB RCSB:2ama, PDBe:2ama, PDBj:2ama
PDBsum2ama
PubMed16641486
UniProtP10275|ANDR_HUMAN Androgen receptor (Gene Name=AR)

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