Structure of PDB 2am4 Chain A

Receptor sequence
>2am4A (length=342) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence]
AVIPILVIACDRSTVRRCLDKLLHYRPSAELFPIIVSQDCGHEETAQVIA
SYGSAVTHIRQPDLSNIAVQPDHRKFQGYYKIARHYRWALGQIFHNFNYP
AAVVVEDDLEVAPDFFEYFQATYPLLKADPSLWCVSAWNDNGKEQMVDSS
KPELLYRTDFFPGLGWLLLAELWAELEPKWPKAFWDDWMRRPEQRKGRAC
VRPEISRTMTFGRKGVSHGQFFDQHLKFIKLNQQFVPFTQLDLSYLQQEA
YDRDFLARVYGAPQLQVEKVRTNDRKELGEVRVQYTGRDSFKAFAKALGV
MDDLKSGVPRAGYRGIVTFLFRGRRVHLAPPQTWDGYDPSWT
3D structure
PDB2am4 X-ray Crystal Structures of Rabbit N-acetylglucosaminyltransferase I (GnT I) in Complex with Donor Substrate Analogues.
ChainA
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D213 D291
Catalytic site (residue number reindexed from 1) D108 D186
Enzyme Commision number 2.4.1.101: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 U2F A I113 A114 C115 R117 D144 C145 Y184 I187 H190 E211 D212 D291 G320 V321 S322 I8 A9 C10 R12 D39 C40 Y79 I82 H85 E106 D107 D186 G215 V216 S217 MOAD: Ki=190uM
PDBbind-CN: -logKd/Ki=3.72,Ki=190uM
BS02 GOL A R131 I139 A160 V161 T162 R26 I34 A55 V56 T57
BS03 GOL A P235 R303 P130 R198
Gene Ontology
Molecular Function
GO:0008375 acetylglucosaminyltransferase activity
Biological Process
GO:0006486 protein glycosylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2am4, PDBe:2am4, PDBj:2am4
PDBsum2am4
PubMed16769084
UniProtP27115|MGAT1_RABIT Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (Gene Name=MGAT1)

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