Structure of PDB 2am2 Chain A

Receptor sequence
>2am2A (length=454) Species: 171101 (Streptococcus pneumoniae R6) [Search protein sequence]
MKLTIHEIAQVVGAKNDISIFEDTQLEKAEFDSRLIGTGDLFVPLKGARD
GHDFIETAFENGAAVTLSEKEVSNHPYILVDDVLTAFQSLASYYLEKTTV
DVFAVTGSNGKTTTKDMLAHLLSTRYKTYKTQGNYNNEIGLPYTVLHMPE
GTEKLVLEMGQDHLGDIHLLSELARPKTAIVTLVGEAHLAFFKDRSEIAK
GKMQIADGMASGSLLLAPADPIVEDYLPIDKKVVRFGQGAELEITDLVER
KDSLTFKANFLEQALDLPVTGKYNATNAMIASYVALQEGVSEEQIRLAFQ
HLELTRNRTEWKKAANGADILSDVYNANPTAMKLILETFSAIPANEGGKK
IAVLADMKELGDQSVQLHNQMILSLSPDVLDIVIFYGEDIAQLAQLASQM
FPIGHVYYFKKTEDQDQFEDLVKQVKESLGAHDQILLKGSNSMNLAKLVE
SLEN
3D structure
PDB2am2 Structure of MurF from Streptococcus pneumoniae co-crystallized with a small molecule inhibitor exhibits interdomain closure
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.3.2.10: UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2LG A F31 R34 A48 R49 Y135 N137 N326 N328 T330 L367 F31 R34 A48 R49 Y135 N137 N326 N328 T330 L367 PDBbind-CN: -logKd/Ki=5.10,IC50=8uM
BindingDB: IC50=8000nM
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0008766 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
GO:0016874 ligase activity
GO:0016881 acid-amino acid ligase activity
GO:0047480 UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Biological Process
GO:0008360 regulation of cell shape
GO:0009058 biosynthetic process
GO:0009252 peptidoglycan biosynthetic process
GO:0051301 cell division
GO:0071555 cell wall organization
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2am2, PDBe:2am2, PDBj:2am2
PDBsum2am2
PubMed16322581
UniProtQ8DNV6

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