Structure of PDB 2aj4 Chain A

Receptor sequence
>2aj4A (length=509) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
VIVPEFNSSAELPRPLAEKCPSIIKKFISAYDAKPDFVARSPGRVNLIGE
HIDYCDFSVLPLAIDFDMLCAVKVLNEKNPSITLINADPKFAQRKFDLPL
DGSYVTIDPSVSDWSNYFKCGLHVAHSFLKKLAPERFASAPLAGLQVFCE
GDVPTGSGLSSSAAFICAVALAVVKANMGPGYHMSKQNLMRITVVAEHYV
GVNNGGMDQAASVCGEEDHALYVEFKPQLKATPFKFPQLKNHEISFVIAN
TLVVSNKFETAPTNYNLRVVEVTTAANVLAATYGVVLLNKGNLRDFMNVY
YARYHNISTPWNGDIESGIERLTKMLVLVEESLANKKQGFSVDDVAQSLN
CSREEFTRDYLTTSPVRFQVLKLYQRAKHVYSESLRVLKAVKLMTTFTAD
EDFFKQFGALMNESQASCDKLYECSCPEIDKICSIALSNGSYGSRLTGAG
WGGCTVHLVPGGPNGNIEKVKEALANEFYKVKYPKITDAELENAIIVSKP
ALGSCLYEL
3D structure
PDB2aj4 Molecular structure of Saccharomyces cerevisiae Gal1p, a bifunctional galactokinase and transcriptional inducer
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.6: galactokinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLA A E59 H60 D62 Y63 N213 G214 D217 K266 Y274 A468 E50 H51 D53 Y54 N204 G205 D208 K257 Y265 A449
BS02 ANP A M77 N95 W123 Y126 T164 G165 G167 S169 S170 S171 F174 S264 N265 K266 M68 N86 W114 Y117 T155 G156 G158 S160 S161 S162 F165 S255 N256 K257
Gene Ontology
Molecular Function
GO:0004335 galactokinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016773 phosphotransferase activity, alcohol group as acceptor
Biological Process
GO:0000411 positive regulation of transcription by galactose
GO:0000435 positive regulation of transcription from RNA polymerase II promoter by galactose
GO:0006012 galactose metabolic process
GO:0016310 phosphorylation
GO:0033499 galactose catabolic process via UDP-galactose
GO:0044281 small molecule metabolic process
GO:0046835 carbohydrate phosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2aj4, PDBe:2aj4, PDBj:2aj4
PDBsum2aj4
PubMed16115868
UniProtP04385|GAL1_YEAST Galactokinase (Gene Name=GAL1)

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