Structure of PDB 2ai7 Chain A

Receptor sequence
>2ai7A (length=194) Species: 1313 (Streptococcus pneumoniae) [Search protein sequence]
SAIERISKAAHLIDMCDIIREGNPSLRTVAEEVTFPLSDQEIILGEKMMQ
FLKHSQDPVMAEKMGLRGGVGLAAPQLDISKRIIAVLVPNIEAYDLEAIM
YNPKIVSHSVQDAALGEGEGCLSVDRNVPGYVVRHARVTVDYFDKDGEKH
RIKLKGYNSIVVQHEIDHINGIMFYDRINEKDPFAVKDGLLILE
3D structure
PDB2ai7 Structural Variation and inhibitor binding in polypeptide deformylase from four different bacterial species
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G71 Q76 C130 L131 H173 E174 H177
Catalytic site (residue number reindexed from 1) G71 Q76 C121 L122 H164 E165 H168
Enzyme Commision number 3.5.1.88: peptide deformylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SB7 A G71 Q76 E128 C130 L131 H173 E174 H177 G71 Q76 E119 C121 L122 H164 E165 H168 MOAD: ic50=0.4uM
PDBbind-CN: -logKd/Ki=6.40,IC50=0.4uM
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
GO:0042586 peptide deformylase activity
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
GO:0043686 co-translational protein modification

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Molecular Function
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Biological Process
External links
PDB RCSB:2ai7, PDBe:2ai7, PDBj:2ai7
PDBsum2ai7
PubMed12538898
UniProtQ8DP79|DEF_STRR6 Peptide deformylase (Gene Name=def)

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