Structure of PDB 2ahr Chain A

Receptor sequence
>2ahrA (length=257) Species: 160490 (Streptococcus pyogenes M1 GAS) [Search protein sequence]
AMKIGIIGVGKMASAIIKGLKQTPHELIISGSSLERSKEIAEQLALPYAM
SHQDLIDQVDLVILGIKPQLFETVLKPLHFKQPIISMAAGISLQRLATFV
GQDLPLLRIMPNMNAQILQSSTALTGNALVSQELQARVRDLTDSFGSTFD
ISEKDFDTFTALAGSSPAYIYLFIEALAKAGVKNGIPKAKALEIVTQTVL
ASASNLKTSSQSPHDFIDAICSPGGTTIAGLMELERLGLTATVSSAIDKT
IDKAKSL
3D structure
PDB2ahr Crystal Structures of Delta(1)-Pyrroline-5-carboxylate Reductase from Human Pathogens Neisseria meningitides and Streptococcus pyogenes
ChainA
Resolution2.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.5.1.2: pyrroline-5-carboxylate reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP A V8 G9 K10 M11 G30 S31 R35 H51 I65 P67 L69 M86 A87 A88 M109 M112 V9 G10 K11 M12 G31 S32 R36 H52 I66 P68 L70 M87 A88 A89 M110 M113
BS02 NAP A I219 S221 I220 S222
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004735 pyrroline-5-carboxylate reductase activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0006561 proline biosynthetic process
GO:0055129 L-proline biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:2ahr, PDBe:2ahr, PDBj:2ahr
PDBsum2ahr
PubMed16233902
UniProtQ9A1S9

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