Structure of PDB 2aho Chain A

Receptor sequence
>2ahoA (length=401) Species: 2287 (Saccharolobus solfataricus) [Search protein sequence]
AWPKVQPEVNIGVVGHVDHGKTTLVQAITGIWTSGMTIKLGYAETNIGVC
ESCKKPEAYVTEPSCKSCGSDDEPKFLRRISFIDAPGHEVLMATMLSGAA
LMDGAILVVAANEPFPQPQTREHFVALGIIGVKNLIIVQNKVDVVSKEEA
LSQYRQIKQFTKGTWAENVPIIPVSALHKINIDSLIEGIEEYIKTPYRDL
SQKPVMLVIRSFDVNKPGTQFNELKGGVIGGSIIQGLFKVDQEIKVLPGL
RVVSYEPIFTKISSIRFGDEEFKEAKPGGLVAIGTYLDPSLTKADNLLGS
IITLADAEVPVLWNIRIKYNLLERVVGAKEMLKVDPIRAKETLMLSVGSS
TTLGIVTSVKKDEIEVELRRPVAVWSNNIRTVISRQIAGRWRMIGWGLVE
I
3D structure
PDB2aho Structural Switch of the gamma Subunit in an Archaeal aIF2alphagamma Heterodimer
ChainA
Resolution3.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D19 K22 T23 T46 H97
Catalytic site (residue number reindexed from 1) D18 K21 T22 T37 H88
Enzyme Commision number 3.6.5.3: protein-synthesizing GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A T23 T46 T22 T37
BS02 ZN A C74 C77 C65 C68
BS03 GNP A D19 G21 K22 T23 T24 M45 T46 G96 N149 K150 D152 S184 L186 D18 G20 K21 T22 T23 M36 T37 G87 N140 K141 D143 S175 L177
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003743 translation initiation factor activity
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0001731 formation of translation preinitiation complex
GO:0006412 translation
GO:0006413 translational initiation
GO:0006414 translational elongation

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Molecular Function
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Biological Process
External links
PDB RCSB:2aho, PDBe:2aho, PDBj:2aho
PDBsum2aho
PubMed16407071
UniProtQ980A5|IF2G_SACS2 Translation initiation factor 2 subunit gamma (Gene Name=eif2g)

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