Structure of PDB 2ags Chain A

Receptor sequence
>2agsA (length=634) Species: 5698 (Trypanosoma rangeli) [Search protein sequence]
MASLAPGSSRVELFKRKNSTVPFEESNGTIRERVVHSFRIPTIVNVDGVM
VAIADARYETSFDNSFIETAVKYSVDDGATWNTQIAIKNSRASSVSRVMD
ATVIVKGNKLYILVGSFNKTRNSWTQHRDGSDWEPLLVVGEVTKSAANGK
TTATISWGKPVSLKPLFPAEFDGILTKEFIGGVGAAIVASNGNLVYPVQI
ADMGGRVFTKIMYSEDDGNTWKFAEGRSKFGCSEPAVLEWEGKLIINNRV
DGNRRLVYESSDMGKTWVEALGTLSHVWTNSPTSNQQDCQSSFVAVTIEG
KRVMLFTHPLNLKGRWMRDRLHLWMTDNQRIFDVGQISIGDENSGYSSVL
YKDDKLYSLHEINTNDVYSLVFVRLIGELQLMKSVVRTWKEEDNHLASIC
TPVVPATPPSKGGCGAAVPTAGLVGFLSHSANGSVWEDVYRCVDANVANA
ERVPNGLKFNGVGGGAVWPVARQGQTRRYQFANYRFTLVATVTIDELPKG
TSPLLGAGLEGPGDAKLLGLSYDKNRQWRPLYGAAPASPTGSWELHKKYH
VVLTMADRQGSVYVDGQPLAGSGNTVVRGATLPDISHFYIGGPRSKGAPT
DSRVTVTNVVLYNRRLNSSEIRTLFLSQDMIGTD
3D structure
PDB2ags Structural and Kinetic Analysis of Two Covalent Sialosyl-Enzyme Intermediates on Trypanosoma rangeli Sialidase.
ChainA
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.18: exo-alpha-sialidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FKD A R36 D60 D97 R246 R315 Y343 R39 D63 D100 R249 R318 Y346
Gene Ontology
Molecular Function
GO:0004308 exo-alpha-sialidase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
Biological Process
GO:0006689 ganglioside catabolic process
GO:0009313 oligosaccharide catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2ags, PDBe:2ags, PDBj:2ags
PDBsum2ags
PubMed16298994
UniProtO44049

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