Structure of PDB 2ag4 Chain A

Receptor sequence
>2ag4A (length=164) Species: 9606 (Homo sapiens) [Search protein sequence]
HMSSFSWDNCDEGKDPAVIRSLTLEPDPIVVPGNVTLSVVGSTSVPLSSP
LKVDLVLEKEVAGLWIKIPCTDYIGSCTFEHFCDVLDMLIPTGEPCPEPL
RTYGLPCHCPFKEGTYSLPKSEFVVPDLELPSWLTTGNYRIESVLSSSGK
RLGCIKIAASLKGI
3D structure
PDB2ag4 Crystal Structure Analysis of Phosphatidylcholine-GM2-Activator Product Complexes: Evidence for Hydrolase Activity.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LP3 A A17 G41 S42 F82 P97 Y116 L145 A17 G41 S42 F82 P97 Y116 L145
Gene Ontology
Molecular Function
GO:0004563 beta-N-acetylhexosaminidase activity
GO:0005319 lipid transporter activity
GO:0005515 protein binding
GO:0008047 enzyme activator activity
GO:0016004 phospholipase activator activity
GO:0016787 hydrolase activity
GO:0030290 sphingolipid activator protein activity
GO:0032428 beta-N-acetylgalactosaminidase activity
Biological Process
GO:0001573 ganglioside metabolic process
GO:0006665 sphingolipid metabolic process
GO:0006689 ganglioside catabolic process
GO:0006869 lipid transport
GO:0007611 learning or memory
GO:0009313 oligosaccharide catabolic process
GO:0019915 lipid storage
GO:0046479 glycosphingolipid catabolic process
GO:0050877 nervous system process
GO:0050885 neuromuscular process controlling balance
GO:0051651 maintenance of location in cell
Cellular Component
GO:0005576 extracellular region
GO:0005764 lysosome
GO:0005829 cytosol
GO:0009898 cytoplasmic side of plasma membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0035578 azurophil granule lumen
GO:0043202 lysosomal lumen
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2ag4, PDBe:2ag4, PDBj:2ag4
PDBsum2ag4
PubMed16216074
UniProtP17900|SAP3_HUMAN Ganglioside GM2 activator (Gene Name=GM2A)

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