Structure of PDB 2ady Chain A

Receptor sequence
>2adyA (length=197) Species: 9606 (Homo sapiens) [Search protein sequence]
SSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQ
LWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHL
IRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMG
GMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRK
3D structure
PDB2ady Structural Basis of DNA Recognition by p53 Tetramers
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A K120 S121 R248 K26 S27 R154 PDBbind-CN: Kd=14nM
BS02 dna A S241 R273 C275 A276 R280 S147 R179 C181 A182 R186 PDBbind-CN: Kd=14nM
BS03 ZN A C176 H179 C238 C242 C82 H85 C144 C148
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0006915 apoptotic process
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2ady, PDBe:2ady, PDBj:2ady
PDBsum2ady
PubMed16793544
UniProtP04637|P53_HUMAN Cellular tumor antigen p53 (Gene Name=TP53)

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