Structure of PDB 2adc Chain A

Receptor sequence

>2adcA (length=208) Species: 9606 (Homo sapiens) [Search protein sequence]

GRIAIPGLAGAGNSVLLVSNLNPERVTPQSLFILFGVYGDVQRVKILFNK
KENALVQMADGNQAQLAMSHLNGHKLHGKPIRITLSKHQNVQLPREGQED
QGLTKDYGNSPLHRFKKPGSKNFQNIFPPSATLHLSNIPPSVSEEDLKVL
FSSNGGVVKGFKFFQKDRKMALIQMGSVEEAVQALIDLHNHDLGENHHLR
VSFSKSTI

3D structure

PDB

2adc Structure of PTB bound to RNA: specific binding and implications for splicing regulation

Chain

Resolution

N/A

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	N448 H457 S459 K485 F487 Q488 K489 K492 M493 N519 R523 V524 S525 S527 K528	N125 H134 S136 K162 F164 Q165 K166 K169 M170 N196 R200 V201 S202 S204 K205
BS02	rna	A	L340 K368 L370 F371 N376 L378 R405 S409 K410 H411 N413 Q415 P417 R418 E422 L426	L17 K45 L47 F48 N53 L55 R82 S86 K87 H88 N90 Q92 P94 R95 E99 L103

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding
GO:0003723	RNA binding

	Biological Process
GO:0006397	mRNA processing

	Cellular Component
GO:0005634	nucleus

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:2adc, PDBe:2adc, PDBj:2adc
PDBsum	2adc
PubMed	16179478
UniProt	P26599\|PTBP1_HUMAN Polypyrimidine tract-binding protein 1 (Gene Name=PTBP1)

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