Structure of PDB 2acz Chain A

Receptor sequence

>2aczA (length=588) Species: 562 (Escherichia coli) [Search protein sequence]

MKLPVREFDAVVIGAGGAGMRAALQISQSGQTCALLSKVFPTRSHTVSAQ
GGITVALGNTHEDNWEWHMYDTVKGSDYIGDQDAIEYMCKTGPEAILELE
HMGLPFSRLDDGRIYQRPFGGQSKNFGGEQAARTAAAADRTGHALLHTLY
QQNLKNHTTIFSEWYALDLVKNQDGAVVGCTALCIETGEVVYFKARATVL
ATGGAGRIYQSTTNAHINTGDGVGMAIRAGVPVQDMEMWQFHPTGIAGAG
VLVTEGCRGEGGYLLNKHGERFMERYAPNAKDLAGRDVVARSIMIEIREG
RGCDGPWGPHAKLKLDHLGKEVLESRLPGILELSRTFAHVDPVKEPIPVI
PTCHYMMGGIPTKVTGQALTVNEKGEDVVVPGLFAVGEIACVSVHGANRL
GGNSLLDLVVFGRAAGLHLQESIAEQGALRDASESDVEASLDRLNRWNNN
RNGEDPVAIRKALQECMQHNFSVFREGDAMAKGLEQLKVIRERLKNARLD
DTSSEFNTQRVECLELDNLMETAYATAVSANFRTESRGAHSRFDFPDRDD
ENWLCHSLYLPESESMTRRSVNMEPKLRPAFPPKIRTY

3D structure

PDB

2acz Structural and computational analysis of the quinone-binding site of complex II (succinate-ubiquinone oxidoreductase): a mechanism of electron transfer and proton conduction during ubiquinone reduction.

Chain

Resolution

3.1 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	F119 T213 W239 Q240 H242 L252 E255 R258 R286 L323 I347 H354 Y355 N398 R399
Catalytic site (residue number reindexed from 1)	F119 T213 W239 Q240 H242 L252 E255 R258 R286 L323 I347 H354 Y355 N398 R399
Enzyme Commision number	1.3.5.1: succinate dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	OAA	A	G51 F126 H242 T254 E255 R286 H354 R399 G401 G402	G51 F126 H242 T254 E255 R286 H354 R399 G401 G402
BS02	FAD	A	G14 A15 G16 G17 S37 K38 S44 H45 T46 S48 A49 Q50 G51 Y165 A166 A201 T202 G203 N214 D221 H354 Y355 E388 G402 S404 L405 L408	G14 A15 G16 G17 S37 K38 S44 H45 T46 S48 A49 Q50 G51 Y165 A166 A201 T202 G203 N214 D221 H354 Y355 E388 G402 S404 L405 L408

Gene Ontology

	Molecular Function
GO:0000104	succinate dehydrogenase activity
GO:0005515	protein binding
GO:0008177	succinate dehydrogenase (quinone) activity
GO:0009055	electron transfer activity
GO:0016491	oxidoreductase activity
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors
GO:0050660	flavin adenine dinucleotide binding

	Biological Process
GO:0006099	tricarboxylic acid cycle
GO:0009060	aerobic respiration
GO:0009061	anaerobic respiration
GO:0019646	aerobic electron transport chain
GO:0022900	electron transport chain

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0045273	respiratory chain complex II (succinate dehydrogenase)

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:2acz, PDBe:2acz, PDBj:2acz
PDBsum	2acz
PubMed	16407191
UniProt	P0AC41\|SDHA_ECOLI Succinate dehydrogenase flavoprotein subunit (Gene Name=sdhA)

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