Structure of PDB 2ac0 Chain A

Receptor sequence
>2ac0A (length=198) Species: 9606 (Homo sapiens) [Search protein sequence]
SSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPV
QLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQH
LIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCM
GGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRK
3D structure
PDB2ac0 Structural Basis of DNA Recognition by p53 Tetramers
ChainA
Resolution1.8 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A A119 K120 S121 R248 A26 K27 S28 R155 PDBbind-CN: Kd=25nM
BS02 dna A S241 R248 R273 C275 A276 R280 S148 R155 R180 C182 A183 R187 PDBbind-CN: Kd=25nM
BS03 ZN A C176 H179 C238 C242 C83 H86 C145 C149
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0006915 apoptotic process
Cellular Component
GO:0005634 nucleus

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:2ac0, PDBe:2ac0, PDBj:2ac0
PDBsum2ac0
PubMed16793544
UniProtP04637|P53_HUMAN Cellular tumor antigen p53 (Gene Name=TP53)

[Back to BioLiP]