Structure of PDB 2ab2 Chain A

Receptor sequence
>2ab2A (length=259) Species: 9606 (Homo sapiens) [Search protein sequence]
LVPQLSTISRALTPSPVMVLENIEPEIVYAGYDSSKPDTAENLLSTLNRL
AGKQMIQVVKWAKVLPGFKNLPLEDQITLIQYSWMSLLSFALSWRSYKHT
NSQFLYFAPDLVFNEEKMHQSAMYELCQGMHQISLQFVRLQLTFEEYTIM
KVLLLLSTIPKDGLKSQAAFEEMRTNYIKELRKMVTKCNNSGQSWQRFYQ
LTKLLDSMHDLVSDLLEFCFYTFRESHALKVEFPAMLVEIISDQLPKVES
GNAKPLYFH
3D structure
PDB2ab2 A Ligand-mediated Hydrogen Bond Network Required for the Activation of the Mineralocorticoid Receptor
ChainA
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SNL A L766 L769 N770 A773 Q776 M807 L810 F829 M845 M852 C942 T945 F956 L44 L47 N48 A51 Q54 M85 L88 F107 M123 M130 C219 T222 F233 BindingDB: IC50=11nM,Ki=2.323nM
External links
PDB RCSB:2ab2, PDBe:2ab2, PDBj:2ab2
PDBsum2ab2
PubMed15967794
UniProtP08235|MCR_HUMAN Mineralocorticoid receptor (Gene Name=NR3C2)

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