Structure of PDB 2aa5 Chain A

Receptor sequence
>2aa5A (length=255) Species: 9606 (Homo sapiens) [Search protein sequence]
ALVPQLSTISRALTPSPVMVLENIEPEIVYAGYDSSKPDTAENLLSTLNR
LAGKQMIQVVKWAKVLPGFKNLPLEDQITLIQYSWMSLSSFALSWRSYKH
TNSQFLYFAPDLVFNEEKMHQSAMYELCQGMHQISLQFVRLQLTFEEYTI
MKVLLLLSTIPKDGLKSQAAFEEMRTNYIKELRKMVTKCSWQRFYQLTKL
LDSMHDLVSDLLEFCFYTFRESHALKVEFPAMLVEIISDQLPKVESGNAK
PLYFH
3D structure
PDB2aa5 A Ligand-mediated Hydrogen Bond Network Required for the Activation of the Mineralocorticoid Receptor
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 STR A L769 N770 Q776 M807 S810 M845 M852 F941 C942 L48 N49 Q55 M86 S89 M124 M131 F214 C215 BindingDB: IC50=14nM,Kd=0.390000nM
External links
PDB RCSB:2aa5, PDBe:2aa5, PDBj:2aa5
PDBsum2aa5
PubMed15967794
UniProtP08235|MCR_HUMAN Mineralocorticoid receptor (Gene Name=NR3C2)

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