Structure of PDB 2aa2 Chain A

Receptor sequence
>2aa2A (length=252) Species: 9606 (Homo sapiens) [Search protein sequence]
LSTISRALTPSPVMVLENIEPEIVYAGYDSSKPDTAENLLSTLNRLAGKQ
MIQVVKWAKVLPGFKNLPLEDQITLIQYSWMSLSSFALSWRSYKHTNSQF
LYFAPDLVFNEEKMHQSAMYELCQGMHQISLQFVRLQLTFEEYTIMKVLL
LLSTIPKDGLKSQAAFEEMRTNYIKELRKMVTSGQSWQRFYQLTKLLDSM
HDLVSDLLEFCFYTFRESHALKVEFPAMLVEIISDQLPKVESGNAKPLYF
HR
3D structure
PDB2aa2 A Ligand-mediated Hydrogen Bond Network Required for the Activation of the Mineralocorticoid Receptor
ChainA
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AS4 A L766 L769 N770 Q776 M807 S810 F829 M845 M852 F941 C942 T945 L40 L43 N44 Q50 M81 S84 F103 M119 M126 F210 C211 T214 BindingDB: IC50=0.305000nM,EC50=0.180000nM,Kd=0.500000nM
External links
PDB RCSB:2aa2, PDBe:2aa2, PDBj:2aa2
PDBsum2aa2
PubMed15967794
UniProtP08235|MCR_HUMAN Mineralocorticoid receptor (Gene Name=NR3C2)

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