Structure of PDB 2a81 Chain A

Receptor sequence
>2a81A (length=235) Species: 554 (Pectobacterium carotovorum) [Search protein sequence]
MVFEENSDEVRVITLDHPNKHNPFSRTLETSVKDALARANADDSVRAVVV
YGGAERSFSAGGDFNEVKQLSRSEDIEEWIDRVIDLYQAVLNVNKPTIAA
VDGYAIGMGFQFALMFDQRLMASTANFVMPELKHGIGCSVGAAILGFTHG
FSTMQEIIYQCQSLDAPRCVDYRLVNQVVESSALLDAAITQAHVMASYPA
SAFINTKRAVNKPFIHLLEQTRDASKAVHKAAFQA
3D structure
PDB2a81 Structural and Mechanistic Studies on Carboxymethylproline Synthase (CarB), a Unique Member of the Crotonase Superfamily Catalyzing the First Step in Carbapenem Biosynthesis.
ChainA
Resolution3.15 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) G62 V67 I80 I84 M108 Q111 E131 G137 C138 S139 D223
Catalytic site (residue number reindexed from 1) G62 V67 I80 I84 M108 Q111 E131 G137 C138 S139 D223
Enzyme Commision number 2.3.1.226: carboxymethylproline synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ACO A N19 P23 G62 D63 F64 N19 P23 G62 D63 F64
Gene Ontology
Molecular Function
GO:0016740 transferase activity
Biological Process
GO:0017000 antibiotic biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2a81, PDBe:2a81, PDBj:2a81
PDBsum2a81
PubMed16096274
UniProtQ9XB60|CARB_PECCC Carboxymethylproline synthase (Gene Name=carB)

[Back to BioLiP]