Structure of PDB 2a68 Chain A

Receptor sequence
>2a68A (length=229) Species: 274 (Thermus thermophilus) [Search protein sequence]
MLDSKLKAPVFTVRTQGREYGEFVLEPLERGFGVTLGNPLRRILLSSIPG
TAVTSVYIEDVLHEFSTIPGVKEDVVEIILNLKELVVRFLNPSLQTVTLL
LKAEGPKEVKARDFLPVADVEIMNPDLHIATLEEGGRLNMEVRVDRGVGY
VPAEKHGIKDRINAIPVDAVFSPVRRVAFQVEDTRLGQRTDLDKLTLRIW
TDGSVTPLEALNQAVEILREHLTYFSNPQ
3D structure
PDB2a68 Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins.
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A V170 S172 V170 S172
BS02 MG A G105 L132 E133 E134 G135 G136 G105 L132 E133 E134 G135 G136
BS03 MG A S66 T67 S66 T67
BS04 MG A R176 W200 R176 W200
BS05 MG A L80 K83 L80 K83
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046983 protein dimerization activity
Biological Process
GO:0006351 DNA-templated transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2a68, PDBe:2a68, PDBj:2a68
PDBsum2a68
PubMed16096056
UniProtQ5SHR6|RPOA_THET8 DNA-directed RNA polymerase subunit alpha (Gene Name=rpoA)

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