Structure of PDB 2a62 Chain A

Receptor sequence

>2a62A (length=319) Species: 10090 (Mus musculus) [Search protein sequence]

SWVWNQMFVLEEFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAGTIFQI
NDITGDIHAIKRLDREEKAEYTLTAQAVDFETNKPLEPPSEFIIKVQDIN
DNAPEFLNGPYHATVPEMSILGTSVTNVTATDADDPVYGNSAKLVYSILE
GQPYFSIEPETAIIKTALPNMDREAKEEYLVVIQAKDMGGHSGGLSGTTT
LTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTAIGRVKANDQDIGENAQS
SYDIIGTALFEITSDAQAQDGVIRLRKPLDFETKKSYTLKVEAANIHIDP
RFSSRGPFKDTATVKIVVE

3D structure

PDB

2a62 Type II cadherin ectodomain structures: implications for classical cadherin specificity.

Chain

Resolution

4.5 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	CA	A	N100 N102 D132 D134 D187	N100 N102 D132 D134 D187
BS02	CA	A	E11 E66 D98 I99 D101 N102 D134	E11 E66 D98 I99 D101 N102 D134
BS03	CA	A	E11 E12 D64 E66 D101	E11 E12 D64 E66 D101
BS04	CA	A	N209 N211 D241 D243 N247 N298	N209 N211 D241 D243 N247 N295
BS05	CA	A	E117 D207 V208 D210 D243	E117 D207 V208 D210 D243
BS06	CA	A	E117 R173 E174 D207 D210 D243	E117 R173 E174 D207 D210 D243

Gene Ontology

	Molecular Function
GO:0005509	calcium ion binding

	Biological Process
GO:0007155	cell adhesion
GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
GO:0098609	cell-cell adhesion

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:2a62, PDBe:2a62, PDBj:2a62
PDBsum	2a62
PubMed	16564015
UniProt	P97291\|CADH8_MOUSE Cadherin-8 (Gene Name=Cdh8)

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