Structure of PDB 2a2c Chain A

Receptor sequence
>2a2cA (length=446) Species: 9606 (Homo sapiens) [Search protein sequence]
ATESPATRRVQVAEHPRLLKLKEMFNSKFGSIPKFYVRAPGRVNIIGEHI
DYCGYSVLPMAVEQDVLIAVEPVKTYALQLANTNPLYPDFSTSANNIDKT
KPLWHNYFLCGLKGIQEHFGLSNLTGMNCLVDGNIPPSSGLSSSSALVCC
AGLVTLTVLGRNLSKVELAEICAKSERYIGTEGGGMDQSISFLAEEGTAK
LIEFSPLRATDVKLPSGAVFVIANSCVEMNKAATSHFNIRVMECRLAAKL
LAKYKSLQWDKVLRLEEVQAKLGISLEEMLLVTEDALHPEPYNPEEICRC
LGISLEELRTQILSPNTQDVLIFKLYQRAKHVYSEAARVLQFKKICEEAP
ENMVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKFGAQGSRLTGAG
WGGCTVSMVPADKLPSFLANVHKAYYQKQSLFATKPGGGALVLLEA
3D structure
PDB2a2c The molecular architecture of human N-acetylgalactosamine kinase.
ChainA
Resolution1.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.157: N-acetylgalactosamine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NG1 A R43 E49 H50 D52 Y53 S145 E179 G187 M189 D190 F240 G401 A402 R42 E48 H49 D51 Y52 S142 E176 G184 M186 D187 F237 G398 A399
BS02 ADP A N83 Y88 W107 Y110 G136 S141 G143 S145 S146 S147 L150 N233 K234 N82 Y87 W104 Y107 G133 S138 G140 S142 S143 S144 L147 N230 K231
Gene Ontology
Molecular Function
GO:0004335 galactokinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0033858 N-acetylgalactosamine kinase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006012 galactose metabolic process
GO:0016310 phosphorylation
GO:0046835 carbohydrate phosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2a2c, PDBe:2a2c, PDBj:2a2c
PDBsum2a2c
PubMed16006554
UniProtQ01415|GALK2_HUMAN N-acetylgalactosamine kinase (Gene Name=GALK2)

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