Structure of PDB 2a14 Chain A

Receptor sequence
>2a14A (length=257) Species: 9606 (Homo sapiens) [Search protein sequence]
FTGGDEYQKHFLPRDYLATYYSFDGSPSPEAEMLKFNLECLHKTFGPGGL
QGDTLIDIGSGPTIYQVLAACDSFQDITLSDFTDRNREELEKWLKKEPGA
YDWTPAVKFACELEGNSGRWEEKEEKLRAAVKRVLKCDVHLGNPLAPAVL
PLADCVLTLLAMECACCSLDAYRAALCNLASLLKPGGHLVTTVTLRLPSY
MVGKREFSCVALEKGEVEQAVLDAGFDIEQLLHSPQSYSVTNAANNGVCC
IVARKKP
3D structure
PDB2a14 The Crystal Structure of Human Indolethylamine N-methyltransferase in complex with SAH.
ChainA
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.49: amine N-methyltransferase.
2.1.1.96: thioether S-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A Y11 Y20 Y25 G63 S64 G65 T67 Y69 D85 F86 T87 N90 D142 V143 L163 L164 A165 A169 Y7 Y16 Y21 G59 S60 G61 T63 Y65 D81 F82 T83 N86 D138 V139 L159 L160 A161 A165 PDBbind-CN: -logKd/Ki=5.70,Ki=2.0uM
BindingDB: Ki=2000nM
Gene Ontology
Molecular Function
GO:0004790 thioether S-methyltransferase activity
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0008170 N-methyltransferase activity
GO:0030748 amine N-methyltransferase activity
Biological Process
GO:0009308 amine metabolic process
GO:0009636 response to toxic substance
GO:0032259 methylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2a14, PDBe:2a14, PDBj:2a14
PDBsum2a14
PubMed
UniProtO95050|INMT_HUMAN Indolethylamine N-methyltransferase (Gene Name=INMT)

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