Structure of PDB 1zys Chain A

Receptor sequence
>1zysA (length=271) Species: 9606 (Homo sapiens) [Search protein sequence]
VPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENI
KKEICINAMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGM
PEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLA
TVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAML
AGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSA
RITIPDIKKDRWYNKPLKKGA
3D structure
PDB1zys Pyrrolo[2,3-b]pyridines Inhibit the Checkpoint Kinase Chk1
ChainA
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D130 K132 E134 N135 D148 T170
Catalytic site (residue number reindexed from 1) D128 K130 E132 N133 D146 T168
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A E7 W9 L11 R74 Y81 E5 W7 L9 R72 Y79
BS02 199 A L15 Y20 V23 A36 K38 E85 Y86 C87 G90 L137 D148 L13 Y18 V21 A34 K36 E83 Y84 C85 G88 L135 D146
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0000077 DNA damage checkpoint signaling
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:1zys, PDBe:1zys, PDBj:1zys
PDBsum1zys
PubMed
UniProtO14757|CHK1_HUMAN Serine/threonine-protein kinase Chk1 (Gene Name=CHEK1)

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