Structure of PDB 1zyd Chain A

Receptor sequence
>1zydA (length=270) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
SLRYASDFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHTEEKLSTIL
SEVMLLASLNHQYVVRYYAAWLERRNFVKKKSTLFIQMEYCENRTLYDLI
HSENLNQQRDEYWRLFRQILEALSYIHSQGIIHRDLKPMNIFIDESRNVK
IGDFGLAKIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMIYPFSTGM
ERVNILKKLRSVSIEFPPDFDDNKMKVEKKIIRLLIDHDPNKRPGARTLL
NSGWLPVKHQDEVIKEALKS
3D structure
PDB1zyd Structural Basis for Autoinhibition and Mutational Activation of Eukaryotic Initiation Factor 2{alpha} Protein Kinase GCN2
ChainA
Resolution2.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D835 K837 N840 D853 T887
Catalytic site (residue number reindexed from 1) D135 K137 N140 D153 T161
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A N840 D853 N140 D153
BS02 ATP A L605 V613 A626 C791 D835 K837 F842 D853 L14 V22 A35 C91 D135 K137 F142 D153
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1zyd, PDBe:1zyd, PDBj:1zyd
PDBsum1zyd
PubMed15964839
UniProtP15442|GCN2_YEAST eIF-2-alpha kinase GCN2 (Gene Name=GCN2)

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