Structure of PDB 1zy7 Chain A

Receptor sequence
>1zy7A (length=378) Species: 9606 (Homo sapiens) [Search protein sequence]
SRQPIPSEGLQLHLPQVLADAVSRLVLGKFGDLTDNFSSPHARRKVLAGV
VMTTGTDVKDAKVISVSTGTKCINGEYMSDRGLALNDCHAEIISRRSLLR
FLYTQLELYLNNKDDQKRSIFQKSERGGFRLKENVQFHLYISTSPCGDAR
IFKARGQLRTKIESGEGTIPVRSNASIQTWDGVLQGERLLTMSCSDKIAR
WNVVGIQGSLLSIFVEPIYFSSIILGSLYHGDHLSRAMYQRISNIEDLPP
LYTLNKPLLSGISNAEARQPGKAPNFSVNWTVGDSAIEVINATTGKDELG
RASRLCKHALYCRWMRVHGKVPSHLLRSKITKPNVYHESKLAAKEYQAAK
ARLFTAFIKAGLGAWVEKPTEQDQFSLT
3D structure
PDB1zy7 Inositol hexakisphosphate is bound in the ADAR2 core and required for RNA editing.
ChainA
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.4.37: double-stranded RNA adenine deaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H394 C451 C516 H89 C146 C194
BS02 IHP A I397 R401 K519 R522 G530 S531 K629 Y658 K662 Y668 K672 E689 K690 I92 R96 K197 R200 G208 S209 K307 Y336 K340 Y346 K350 E367 K368
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004000 adenosine deaminase activity
Biological Process
GO:0006396 RNA processing

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1zy7, PDBe:1zy7, PDBj:1zy7
PDBsum1zy7
PubMed16141067
UniProtP78563|RED1_HUMAN Double-stranded RNA-specific editase 1 (Gene Name=ADARB1)

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