Structure of PDB 1zy5 Chain A

Receptor sequence
>1zy5A (length=271) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
SLRYASDFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHTEEKLSTIL
SEVMLLASLNHQYVVRYYAAWLERRNFVKKKSTLFIQMEYCENGTLYDLI
HSENLNQQRDEYWRLFRQILEALSYIHSQGIIHRDLKPMNIFIDESRNVK
IGDFGLAKNVHRAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMIYPFSTG
MERVNILKKLRSVSIEFPPDFDDNKMKVEKKIIRLLIDHDPNKRPGARTL
LNSGWLPVKHQDEVIKEALKS
3D structure
PDB1zy5 Structural Basis for Autoinhibition and Mutational Activation of Eukaryotic Initiation Factor 2{alpha} Protein Kinase GCN2
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D835 K837 N840 D853
Catalytic site (residue number reindexed from 1) D135 K137 N140 D153
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP A G606 Q607 V613 E789 Y790 C791 F842 D853 G15 Q16 V22 E89 Y90 C91 F142 D153
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1zy5, PDBe:1zy5, PDBj:1zy5
PDBsum1zy5
PubMed15964839
UniProtP15442|GCN2_YEAST eIF-2-alpha kinase GCN2 (Gene Name=GCN2)

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