Structure of PDB 1zxm Chain A

Receptor sequence
>1zxmA (length=373) Species: 9606 (Homo sapiens) [Search protein sequence]
SVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVGINYREVTFV
PGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWNNGKGIPVV
EHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFT
VETASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKM
QSLDKDIVALMVRRAYDIAGSTKDVKVFLNGNKLPVKGFRSYVDMYLKDK
LDETGNSLKVIHEQVNHRWEVCLTMSEKGFQQISFVNSIATSKGGRHVDY
VADQIVTKLVDVVKKKNAVKAHQVKNHMWIFVNALIENPTFDSQTKENMT
LQPKSFGSTCQLSEKFIKAAIGC
3D structure
PDB1zxm Nucleotide-dependent Domain Movement in the ATPase Domain of a Human Type IIA DNA Topoisomerase.
ChainA
Resolution1.87 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP A N91 N95 I125 I141 S148 S149 G161 R162 N163 G164 Y165 G166 A167 K168 T215 K378 N63 N67 I97 I113 S120 S121 G133 R134 N135 G136 Y137 G138 A139 K140 T187 K346
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:1zxm, PDBe:1zxm, PDBj:1zxm
PDBsum1zxm
PubMed16100112
UniProtP11388|TOP2A_HUMAN DNA topoisomerase 2-alpha (Gene Name=TOP2A)

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